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Cellular Aging & Longevity NAD+ is crucial for activating sirtuins, proteins that regulate aging and inflammation, and promote healthy cell function

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Chronic diseases such as Crohn's, celiac disease and gastritis can impair vitamin B12 absorption

The vitamin is then transferred to TC2, which serves as the circulating plasma transporter, hereditary defects in the production of TC2 and its receptor may produce functional deficiencies in B 12 and infantile megaloblastic anemia, and abnormal B 12 related biochemistry, even in some cases with normal blood B 12 levels