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For example, cyclooxygenase (COX) inhibitors are utilized as anti-inflammatory drugs

10.1016/j.chroma.2017.05.062 146 WangY.TianY.ZhangN.LiX.WangX.WangW.et al (2021)

Despite the remarkable clinical efficacy of immunotherapies, including immune checkpoint inhibitors (ICIs) and chimeric antigen receptor (CAR)-T cells, across various tumor types, patient responses remain heterogeneous, with some tumors developing resistance through immune evasion strategies

Prodrugs, on the other hand, remain inactive against cancers until they are activated, and this delayed release mechanism limits their treatment potency