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163 FOXO3 also contributes to the metabolic control of autophagy by upregulating glutamine synthetase, thereby increasing intracellular glutamine and disrupting mTORC1 lysosomal localization, which relieves the mTOR-mediated inhibition of autophagy

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For instance, P115 and GRASP65 trigger apoptosis via the ERK/p53/PUMA pathway or Fas-mediated signaling, respectively, whereas Bruce and GAAP decrease apoptosis via caspase-9, Smac and p53 inhibition, and Ca 2+ signaling downregulation [93]

doi: 10.1016/j.jff.2015.06.040 102