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This could be due to impaired SREBP2 translocation to the nucleus in rSCC-61 cells a hypothesis supported by the cumulative action of insulin induced genes (INSIG1/2) and 24-OH oxysterol, which are both significantly higher in rSCC-61 ( Figure S6B )

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HDACs influence autophagy epigenetically by shaping chromatin accessibility at ATG loci and posttranslationally through the deacetylation of key autophagy regulators (Fig