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Thus, in commercial jet aircraft, which are pressurised to around 7000 ft., healthy normal observers have slightly reduced rod sensitivity and some individuals, particularly those with heart or lung disease, may experience symptoms of dimmed vision, fatigue, nausea, headaches, loss of consciousness, and (on extended flights) even pulmonary edema or death from altitude sickness (212)

687 During targeted drug therapy, DNA methylation can also affect cellular viability, giving rise to resistance to targeted therapy