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Several compounds have been shown to modulate ferroptosis in thyroid cancer, including sorafenib, which inhibits oxidative stress pathways and induces ferroptosis ( 3.3.2 Factors inhibiting Several factors can impede the induction of ferroptosis, including iron deficiency, elevated ferritin expression, antioxidant systems, and the presence of iron chelators

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While hypercalcemia involves dysregulation of calcium homeostasis often mediated by parathyroid hormone-related protein and osteoclast activation, it shares with copper dysregulation a common theme of metal ion imbalance in cancer pathophysiology