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Animal studies suggest relatively rapid distribution following injection, with activity observed at both local and systemic sites

However, side effects and complications can include: itchy skin low blood pressure slowed breathing loss of bladder control fever flushed chest or face anxiety difficulty sleeping changes in the menstrual cycle diarrhea nausea temporary increase in blood sugar In severe breathing difficulty nerve damage prolonged numbness abscesses bleeding allergic reaction adrenal suppression epidural bruising infection spinal headache pain in the lower limbs or back paralysis Doctors may use a nerve block spinal injection to treat acute or chronic pain that may originate in the spine and can radiate to the arms, legs, buttocks, and neck

The limited plant diversity and hardstanding on the previous site was replaced with a variety of plant species and more absorbent surfaces

Dose optimization depends on specific research objectives, administration route, and whether acute effects or long-term structural changes are being measured