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Skin lightening was noticed in a patient as a side effect of large doses of glutathione, which was given for some other disease, and then onwards, it became more popular as a skin lightening agent

We found no difference between the two groups (Supplementary Fig

An impairment of this enzyme is associated with an increase in the cellular SAH concentration, which can ultimately result in the inhibition of methyltransferases and is associated with hypomethylation [65]

These amino acids also participate in signal transmission as neurotransmitters, and any change leading to an imbalance in neurotransmitters could alter the metabolic pathways in the brain, potentially leading to diseases of the central nervous system