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2 IV Acetadote protects liver cells in 2 ways: It helps replenish glutathione It binds to and removes NAPQI Return to top The maximum adult therapeutic dose of acetaminophen is 4 grams/24 hours 3 The maximum dose for children less than 12 years is 75 mg/kg 4 Acute overdose is defined as ingestion of 150 mg/kg or 12 grams/24 hours 4 Four stages of acetaminophen overdose 5 Return to top When time is liver, timing is critical Treatment Recommendations The following recommendations are related to acute acetaminophen ingestion