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This rare but potentially fatal syndrome can occur as the result of an interaction between MAOIs and drugs that have strong serotonergic effects, for example, other antidepressants, synthetic opioids, and some triptan migraine medications.24,34 To avoid serotonin syndrome, contraindicated medications should not be taken for 1 to 2 weeks before initiating therapy with the MAOI or for 2 weeks after stopping MAOI therapy

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