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Medgranate, Medinutrex, Catania, Italy) used in this study was derived from Wonderful variety pomegranate by-products (exhausted peels, membranes, and arils) via industrial drying to 5% moisture, hydroalcoholic extraction (ethanol/water 60:40 v/v, 1:10 w/v, 24 h stirring), alcohol recovery, and spray-drying (30% yield), and has been previously characterized and validated for its polyphenolic profile and bioactivity in in vitro models of prostate cell lines demonstrating antioxidant and anti-proliferative effects (Consoli et al., 2023)

Phase 4: Maintenance (long-term) Once you've identified your optimal concentration, maintenance phase focuses on consistent use with periodic reassessment

Methylation of the viral genome not only alters the host genome, but also contributes to pathogen evasion of the host immune system

In situations such as metastatic breast cancer where a discrete number of hot-spot mutations are commonly clonal, restricted assays have been used [11, 34]