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Amino acid metabolism is pivotal in regulating the metabolic reprogramming and functional activities of B-cells, a process that is of significant importance for the immune response and the modulation of inflammation within the body

[DOI] [PubMed] [Google Scholar] 30.Merlot B., Dispersyn G., Husson Z., Chanavaz-Lacheray I., Dennis T., Greco-Vuilloud J., Fougre M., Potvin S., Cotty-Eslous M., Roman H., Marchand S

Signs and symptoms [edit] LNS is characterized by three major hallmarks: neurologic dysfunction, cognitive and behavioral disturbances including self-mutilation, and uric acid overproduction (hyperuricemia)

Moreover, antibody approach to inhibit the c-MET/HGF pathway is also under investigation, both using antibodies against the ligand (Burgess et al, 2006) as well as the receptor (Nguyen et al, 2003)