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This revealed significant changes in chromatin accessibility at liver genes or regulatory sequences, including APOA1 , CYP2E1 , FGB , Fibrinogen Gamma Chain ( FGG ), and Translocase of Outer Mitochondrial Membrane 40 ( TOMM40 ) (Fig

Since major antioxidant protection of living systems is maintained by the antioxidant enzymes, a significant effort is being devoted to the development of therapeutic strategies centered on the design, in vitro, and clinical studies of enzyme mimetic compounds