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thiazide diuretics, (furosemide)

Therefore, we hypothesize that deregulated homocysteine metabolism in homocystinuria with severe hyperhomocysteinemia will lead to the cyclization of homocysteine into homocysteine thiolactone, which may render LDL less susceptible to oxidation

doi: 10.1002/art.1780330311 [DOI] [PubMed] [Google Scholar] 557

For instance, exercise can induce the expression of PGC-1 in skeletal muscles and the heart, or by activating the adenosine 5-monophosphate (AMP)-activated protein kinase (AMPK)/PGC-1 signaling pathway, thereby increasing the number and function of mitochondria, enhancing ATP synthesis capacity, and improving the tolerance of the heart to hypoxia