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Studies in rodent models suggest that the insulin-antagonistic effects of GH in adipose and skeletal muscle involve suppression of insulin-stimulated PI3-kinase activity (60,64)

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doi: 10.3389/fnins.2018.00386 Received 27 February 2018 Accepted 22 May 2018 Published 06 June 2018 Volume 12 - 2018 Edited by Victor Tapias, Cornell University, United States Reviewed by Carmen Sandi, cole Polytechnique Fdrale de Lausanne, Switzerland

To better comprehend the role of an increased intestinal permeability in GI diseases, it is crucial to understand some basic concepts on how different molecules cross the intestinal epithelium and how intestinal permeability can be evaluated in humans