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Moreover, it has been recently proven that IGF-1 central administration also induced improvement in insulin sensitivity [291], meaning that this sudden rise after exercise or treatment could be of benefit not only in the periphery, but acting centrally

Nature Genetics 41 (2): 234239

Methionine, Inositol, and Choline (MIC)

Besides DPN, in which the pathways leading to increased oxidative stress are well-described, oxidative stress also plays a prominent role in PN of etiologies other than diabetes mellitus, e.g., in chemotherapy-induced PN (CIPN) and alcohol-induced PN (AIPN)