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A validated method to assess glutathione peroxidase enzyme activity

doi: 10.1038/s12276-020-00500-y 77 FanYChengHLiuYLiuSLoweSLiYet al

A lot of vitiligo patients are often diagnosed with Vitamin B9 deficiency and when these levels are low, it contributes to elevated levels of homocysteine, which triggers oxidative stress, which is particularly damaging to the melanocytes

While this idea is somewhat simplified, its intriguing His hypothesis suggests that the sudden influx of B12 can kickstart repair processes, and if there has been long-standing damage, the rapid onset of these processes might overwhelm the system, causing a temporary worsening of symptoms