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Its important to keep in mind that the M1/M2 classification is a simplification of a more complex spectrum

In a phase 2 dose-finding trial, once-weekly Cagrilintide produced clinically meaningful weight loss about 10.8% at the 4.5 mg dose over 26 weeks with gastrointestinal effects the most common adverse events [1]

In vitro experiments further disclosed the inhibitory effect of sUA on the monocyte Toll-like receptor (TLR) signaling pathway, which in turn reduces the migration capability of classical monocytes ( Macrophages Macrophages in most tissues have diverse functions, including initiating immune and inflammatory responses toward pathogens, maintaining tissue homeostasis, and contributing to tissue repair and remodeling ( Figure 2 )

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