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Front Cell Dev Biol, 9 , 734897

Key signaling networks are dysregulated in patients with the adipose tissue disorder, lipedema

This framework would be implemented by considering three key components

These observations also highlight that therapeutic approaches should be directed at specific aspects of astrocyte reactivity, for example astrocyte Ccl2 production, rather than at attenuating reactivity per se, which may lead to unexpected and undesirable consequences