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Cell cycle arrest, DNA damage repair, apoptosis, and other crucial functions can be compromised when p53 is not allowed to enter the nucleus

The main signaling pathways downstream of the IGF-1 receptor are Ras/MAPK and PI3K/Akt, while these two pathways are responsible for the glucose and lipid metabolism in the liver ( Crosstalk Between Circadian Clock System and GH/IGF-1 Axis Regulatory Effect of the GH/IGF-1 Axis on the Circadian Clock System There are very few reports to identify the regulatory effect of the GH/IGF-1 axis on the circadian clock system

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Given the diverse functions of glutathione it is clear that an expanded family of glutathione synthetases could be involved in numerous aspects of the plant-nematode interaction