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During atherosclerotic plaque formation, endothelial barrier, aberrant NO production, ROS production, and pro-inflammatory and pro-coagulative factors cause endothelial dysfunction, which enhances LDL transcytosis, upregulation of LDL oxidation, activation of blood platelet and leukocytes [33]

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L-asparaginase: therapeutic and toxic effects in patients with neoplastic disease

A Phase II clinical trial involving 164 patients was recently showed that in patients with HER2-metastatic breast cancer, addition of indoximod, theIndoleamine 2,3-dioxygenase 1 (IDO1) pathway inhibitor, to taxane did not improve PFS compared with taxane alone (300)