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10.1021/jf3010349 146 NupurP.PaulM.VarunP.PeterR

Rothen, D

Enhanced Detoxification Glutathione is a vital component in the body's detoxification process

The observation that PARP inhibition partly rescues vitamin C-treated cells may suggest that the toxic effect of DHA uptake is not caused by ROS alone, since restoring NAD + levels and glycolysis with the PARP inhibitor may actually decrease PPP flux and NADPH production, and aggravate the redox stress