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615 The neuroprotective effects of GLP-1R agonists in PD are supported in numerous preclinical studies and have been attributed to their ability to restore insulin signaling, reduce glial activation, neuroinflammation, and oxidative stress

Without adequate collagen production and remodeling, injuries to these tissues struggle to regenerate properly, often resulting in scar tissue thats weaker and less functional than the original tissue

Consistent with this hypothesis, recent studies identified various subgroups of mDA neurons through single-cell RNA-seq analysis and established that mDA neuron diversity emerges during postmitotic development

a brain 18 F-FDG-PET study