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A study by Kompel and colleagues in 2019 caused concern when they reported four main adverse joint findings observed in patients following intra-articular corticosteroid injections of the hip: accelerated osteoarthritis progression (6%), subchondral insufficiency fracture (0.9%), complications of avascular necrosis (osteonecrosis) (0.7%), and rapid joint destruction, including bone loss (0.7%)

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Moreover, there is a risk of developing tolerance or dependence on weight loss pills, which may result in reduced efficacy over time or difficulty in maintaining weight loss once the medication is discontinued

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