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We overexpressed separately the endogenous gene in the first step of the GSH biosynthetic pathway, as well as the gene encoding the bacterial single step multicatalytic enzyme LmgshF and StgshF , under the control of a strong constitutive promoter ( TDH3 )

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Extensive genome-wide profiling of AML blasts reveals widespread reduction of histone H3 acetylation at promoter regions, correlating with transcriptional repression of genes such as PRDX2, whose silencing is associated with poorer prognosis and unchecked leukemic proliferation

[355 356 357 358] For the July 1, 2020, through June 30, 2021 measurement period, the risk-standardized readmission rate from the hospital-wide population ranged from 9.9 to 22.5 percent, showing a performance gap across hospitals with wide variation and an opportunity to improve quality