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How to Administer a B12 injection to Yourself There are two ways to self-inject vitamin B12: Subcutaneously, or just below the skin, and intramuscularly, which goes directly into the muscle, says Foxx

Key differences in bioavailability: Prescription injections: High bioavailability due to direct delivery into the bloodstream OTC oral supplements: Variable bioavailability due to gastrointestinal absorption factors Understanding the differences between prescription B12 injections and OTC supplements helps healthcare providers tailor treatments