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PCOS patients have an increase in the oxidative stress with generation of excessive amounts of reactive oxygen species (ROS) and reduction of antioxidant capacity

Traditional hormonal avenues of treatment are also explored with repurposed medicines, like progestogens (two), GnRH antagonists (one) and other gynaecological medications such as fezolinetant, marketed for treatment of menopause related vasomotor symptoms (in Phase II), and three drugs initially developed for treating breast cancer (tamoxifen, raloxifene, letrozole)

Terahertz waves (ferroptosis-inhibiting EMFs, 34.5 THz) suppress ferroptosis through a direct mechanism targeting iron metabolism: they inhibit iron-transferrin binding, thereby reducing intracellular Fe 2+ accumulation, lipid peroxidation, and malondialdehyde (MDA) levels [16] [Figure 1]

However, as we age or face various health challenges, our body's natural levels of glutathione can decline, leading to an increased interest in supplementation