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The use of dehydroalanine (Dha) in a peptide sequence provides an ideal target for Michael addition, and has been demonstrated as a handle for peptide modification (Zhu and van Der Donk, 2001

Rab7 overexpression in mice was associated with increased autophagic activity [75], a mechanism proposed to lower cholesterol in NPC mutant cells [10, 76] that is possibly normalized in drug-treated NPC1 mutant cells in this study, as judged by the reduced amounts of autophagy markers

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