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Therefore, the changes in the brain fatty acid levels might be induced by oxidative stress, as demonstrated by an increase in free radical generation and MDA, AOPP, LDH, and LOOH levels, mainly in the FS group

Journal of Gastroenterology and Hepatology 2008 23(11) 1657-61

Besides, increased tryptamine production can be associated with decreased circulating tryptophan and serotonin synthesis in the brain and could represent one mechanism by which tryptamine influence behavior [214]

The current consensus among many practitioners is that some variants in CBS (especially the CBS 699) causes homocysteine to move down too quickly (not braking enough), stressing SUOX, creating excess glutamate, and stressing the adrenals