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Abbreviations: IL, Interleukin

& Korsmeyer, S.J

Proteomic analysis of the nucleus of the patients lens versus the controls lens Ninety-five DEPs, comprising 51 upregulated and 44 downregulated proteins, were identified in the patients nucleus compared to controls, as illustrated in the volcano plot (Figure 5A)

MnO also has glutathione peroxidase-like activity, promoting the oxidation of GSH thiol groups (-SH) into oxidized glutathione disulfide (GSSG) through the reaction: MnO + 2GSH Mn 2 + GSSG + 2HO