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Consequently, Vitamin D was proposed as a potentially safer adjuvant treatment option for the management of depressive symptoms.Moreover, while long-term use of SSRIs may result in adverse effects such as decreased bone density [86], Vitamin D has been shown to promote bone health [15]

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These results, which suggest that D-Nle-Tyr-Ile-NH(CH 2 ) 5 CONH 2 is likely to be relatively hydrophobic, are in agreement with the outcome of QSAR modeling estimates generated by ADMET Predictor that calculated an octanol:water partition coefficient of 28.18 for D-Nle-Tyr-Ile-NH(CH 2 ) 5 CONH 2 (Table 6)

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