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However, both astrocytes and microglia are now considered to have a wide spectrum of activation phenotypes, and the loss of their neuroprotective functions toward potentially neurotoxic roles is directly related to the stage and severity of the neurodegenerative process ( Microglial cells are able to protect neural tissue against harmful stimuli such as pathogen-associated molecular patterns (PAMPs) and DAMPs, which are recognized by microglia-expressed receptors such as TLRs, oligomerization domain nuclear receptors or viral receptors (Stephenson et al., 2018)

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