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treats motor symptoms, potentially with fewer doses per day Vyalev A 24hour continuous, under-the-skin levodopa + carbidopa infusion that eases motor symptoms, dyskinesia and fluctuations (ups and downs) Onapgo A 16-hour under-the-skin apomorphine infusion that eases motor symptoms and complications Adaptive Deep Brain Stimulation A self-adjusting system that senses brain signals and responds in real time to manage motor symptoms Both-sided (bilateral) Focused Ultrasound A noninvasive surgical technique that uses ultrasound to destroy tiny areas of brain that cause motor symptoms and complications These are all reformulations of existing medication or technology so are they true advancements

doi: 10.1186/s12943-025-02491-8 9 SafariMHRahimzadehPAlaeiEAlimohammadiMEsfandiariNDaneshiSet al

The therapy helps to improve fat oxidation, which can lead to noticeable reductions in body fat, particularly around the belly and other trouble areas

Ethics statement The studies involving humans were approved by The Third People's Hospital of Bengbu Affiliated to Bengbu Medical University