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These include the polyol pathway and the hexosamine pathway (Figure 2, the pathways in blue), PKC activation, and the advanced glycation pathway [72]

This rigidity improves stability and drug entrapment efficiency (EE) through denser packing of lipid chains

12 This hypothesis reframes the clinical distinction between RBD-PD and non-RBD-PD as potentially rooted in divergent pathogenic origins and provides a falsifiable biological framework for mechanistic investigation