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NLRP3, Oxidative Stress, and Inflammation Healthy cells balance reactive oxygen species (ROS) production with the synthesis and regeneration of small molecule antioxidants, as well as with enzymes that perform antioxidant, detoxification, and repair functions

These findings suggest the inclusion of NAC as an important component of comprehensive CAP control regimens [63]

Overall, the above results show that senescent cells display high levels of ROS, increased Fe 2+ and alterations in lipid metabolism that prime them for ferroptosis, a fate prevented by GPX4 upregulation

Given that lipophagy supplies FAs to boost FAO and TCA in mitochondria, we then reasoned that loss of LEC-autophagy could result in a concomitant downregulation of CPT1A levels, further impairing the overall capacity of the LEC to utilize FAs as energy source