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Though traditionally viewed as immune-privileged, the CNS possesses its own immune defenses, with microglia acting as the primary immune effectors and constituting the predominant immune population in the CNS [120]

The result is sustained caloric deficit without the metabolic adaptation that makes dietary restriction alone so difficult to maintain long-term

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Higher relative abundance of proinflammatory bacteria like Eggerthella, Atopobium was found to be increased, and decreased relative abundance of Faecalibacterium in the subjects with MDD (Knudsen et al., 2021)