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Ab is an antibody which comprises a human lgG4 isotype constant region, or a mutant or chemically modified lgG4 constant region, wherein said mutant or chemically modified constant region confers no or decreased ADCC activity to said antibody when compared to a corresponding antibody with wild type lgG4 isotype constant region

Interestingly, XYS may exert its antidepressant effects by regulating gut microbiota composition and restoring abnormal levels of cecal metabolites (Lv et al., 2021)

These factors may influence effect estimates and limit generalizability

Thymus and activation-regulated chemokine binds to the chemokine receptor CCR4 and induces chemotaxis in T cells, therefore acting as a proinflammatory factor in AD