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[65] This leads to high ferritin levels and low transferrin saturation, a pattern known as "functional iron deficiency." In this condition, iron availability is restricted even when total body iron stores are adequate, contributing to anemia common in inflammatory bowel diseases and chronic infections

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Moderate to high coffee consumption among "slow" metabolizers has been associated with a higher risk of heart attack, heart disease, hypertension, and a lack of "protective" effects against some cancers when compared to those with the "fast" metabolizing variation of CYP1A (Cornelis, et al