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Therefore, the biological effects that detected in this study are likely to reflect the combined action of polysaccharides and other coexisting bioactive compounds, rather than the immunomodulatory potential of polysaccharides alone 62,63

10.1002/gps.1376 Int

The observation that cholinesterase inhibitors could improve apathy symptoms in AD patients further suggests that the basal forebrain, the major structure hosting central cholinergic neurons, may be involved in apathy in AD

To describe disease associations in relation to years of additional aging in the main text, we took the coefficient for the trait variablewhich provides an estimate of the mean difference in z -scored age gaps between disease and controland converted that to an estimate of mean difference in raw age gaps, using the standard deviation of raw age gaps provided in Supplementary Table 8