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As rotenone is a strong inhibitor of the mitochondrial complex I, the antioxidative effects of pomegranate treatment observed in rotenone-injected rats [26] can be explained by ameliorating mitochondrial dysfunction in oxidative stress mediated by UA [98]

In another trial, very high-dose vitamin D supplementation (50,000 IU/week for 24 weeks) had no effect on physical performance in elderly individuals with heart failure