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The 2017 hypermobile EDS criteria in Figure 2 specify that if the Beighton score is one point below age-specific and sex-specific cutoffs for generalized joint hypermobility, the next step is to administer a validated five-part questionnaire to help determine whether the patient has generalized joint hypermobility, a necessary criterion for the diagnosis of hypermobile EDS

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Research shows that symptoms usually come on suddenly and can range in severity

MAO-B, monoamine oxidase B