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Although these studies have benefited greatly from our extensive knowledge of the pathophysiology of PD [291], a clear therapeutic principle has not yet emerged, complicating the search for more effective therapy targets or treatment strategies for PD (including on demand, biomarker-based therapy) or other movement disorders

However, in cultures of the SEV group, the reduction of CCL3 by B12 did not reach statistical significance and intracellular IL-1B levels were very low, close to the detection limit of the technique, suggesting that, in severe COVID-19, leukocytes are more prone to promptly export IL-1B

Older adults may respond differently to therapy and may need closer monitoring, particularly if they have other endocrine, metabolic, or cardiovascular conditions