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Nociplastic pain A clinical definition of pain arising from altered nociception, despite no evidence of tissue damage causing the activation of nociceptors or evidence of disease or lesions of the somatosensory system causing the pain

Transcriptomically distinct CAF subtypes have been identified in iCCA tumours, categorizing them mainly into myofibroblastic CAFs enriched in extracellular matrix (ECM)-related genes 78,85,86 , and vascular or inflammatory CAFs enriched in cytokine and growth factor transcripts (such as hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), HB-EGF, IL-6 and CXCL12), with CD146 + vascular CAFs being the most abundant subtype described in human iCCA 86

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