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This notion is mainly based on the extensive inter-individual variations observed in the efficacy of standard protocols used in the treatment of diseases, such as depression, cancer, hypertension, epilepsy and diabetes, as well as in the drug-related adverse reactions and toxicity outcomes ( Drug Metabolism Every drug entering the body is recognized as a threat of homeostasis and the detoxifying systems are activated ( During drug metabolism of Phase I, cytochrome P450s (CYPs), flavin-containing monoxygenases (FMO) and epoxide hydrolases (EH) are the main families of enzymes that catalyze the biotransformation of xenobiotics including drugs

Iron overload can be caused by an increase in dietary iron absorption in hereditary hemochromatosis patients [16] and by multiple blood transfusions in -thalassemia patients

Almeida AF, Borge GIA, Piskula M, Tudose A, Tudoreanu L, Valentov K, Williamson G, Santos CN (2018) Bioavailability of quercetin in humans with a focus on interindividual variation

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