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Should vaping mimic these transitional effects of traditional NRTs, it is possible that individuals who vape frequently may see reductions in CPD during this pre-quit period of dual-use, and may be building up to eventual cessation

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A 2006 double-blind crossover study published in Psychopharmacology found that transdermal nicotine significantly improved depressive symptoms in nonsmokers with major depressive disorder, suggesting that nicotinic receptor activation can enhance mood independently of smoking-related factors

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