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MDM2 overexpression is a common feature in lung cancers and the MDM2-p53 loop contributes to chemotherapeutic resistance in human malignancies ( Tuberculosis, pneumonia and more recently COVID-19 are major causes of death in PWH under ART ( Mtb and here we extended these findings to SARS-CoV-2 ( ex vivo SARS-CoV-2 challenge does have a major impact on COVID-19 outcomes in people on PrEP, our results support the need for more detailed longitudinal epidemiological data to assess the clinical implications of our findings

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