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These structural insults further limit a cells ability to detoxify and recover from oxidative stress

In addition to KRAS G13C , we also investigated the reactivities towards KRAS G12C 1169 (Cys-light) and KRAS wt 1169 , where no to very low modification was observed, indicating good overall selectivity towards Cys13 (Figure S1)

171 In our recent investigation of FM, we observed a distinct developmental trajectory of neutrophils upon their migration to the heart, where they continuously recruited peripheral neutrophils through the Cxcl2/Cxcl3-Cxcr2 axis, leading to acute neutrophil accumulation in the myocardium