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If HbA1C levels are 9.0% or higher, initial treatment may comprise two or three medications at maximal dosages

10) Rare Genetic Disorders Some rare inherited genetic disorders can increase non-HDL cholesterol levels Non-HDL Cholesterol and Heart Disease Non-HDL-C is strongly associated with an increased risk of developing as well as dying from heart disease

Katsube et al., 2022

PEX12, the pathogenic gene of group III Zellweger syndrome: cDNA cloning by functional complementation on a CHO cell mutant, patient analysis, and characterization of PEX12p