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By forcing proximity between the target protein and the E3 ligase, PROTAC induces proximity-driven polyubiquitination of the POI, i.e., the proximity forced by the PROTAC results in the transfer of the ubiquitin units from the E3 ligase to the POI 23

PAI-1 is believed to play a role in diabetic neuropathy, although further studies are required to fully elucidate its function [22], as it likely impairs fibrinolysis in neural blood vessels, promoting nerve ischemia and oxidative stress

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