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Sandstrom et al., 2017), solitary nucleus, and catecholaminergic neurons in the pituitary-adrenal system (Edmonds and Edwards, 1996), all of which subsequently decrease the dopamine concentration in the brain (Barbeau et al., Studies have indicated that PQ dopaminergic neurotoxicity is associated with increased cellular oxidative stress and neuroinflammation, which induces -synuclein aggregation and impairs neurons (Manning-Bog et al., 2002

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some individuals report sleep disturbances Foods and Substances to Avoid Around Dosing To optimize AOD-9604s effectiveness, avoid the following in the hour before and 30-60 minutes after administration: All foods (proteins, carbohydrates, fats trigger insulin response) Caloric beverages including juice, milk, sports drinks, protein shakes Artificial sweeteners (may trigger minor insulin response in some individuals) Coffee with cream or sugar (black coffee or tea without additives is acceptable) Acceptable During Dosing Window: Water, black coffee, unsweetened tea, electrolyte water (zero-calorie), and medications as prescribed

Amantadine (Symmetrel) can be taken in multiple daily doses, or in an extended-release formulation (Gocovri) that maintains a high level of amantadine in the body throughout the day and has shown good results in reducing dyskinesia